Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also demonstrate strong associations. Currently however, the extent of gene-environment or gene-gene interactions in myopia is unknown. We tested the hypothesis that refractive error-associated variants exhibit effect size heterogeneity, a hallmark feature of genetic interactions. Of 146 variants tested, evidence of non-uniform, non-linear effects were observed for 66 (45%) at Bonferroni-corrected significance (Pā€‰

Original publication

DOI

10.1038/s42003-019-0387-5

Type

Journal article

Journal

Commun Biol

Publication Date

2019

Volume

2

Keywords

Genetic interaction, Refractive errors, Adult, Aged, Educational Status, Epistasis, Genetic, Female, Gene Expression Profiling, Gene Expression Regulation, Gene-Environment Interaction, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Laminin, Male, Middle Aged, Myopia, Penetrance, Phenotype, Polymorphism, Single Nucleotide, Regression Analysis