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In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p 

Original publication

DOI

10.1038/s41467-019-12283-6

Type

Journal article

Journal

Nat Commun

Publication Date

31/10/2019

Volume

10

Keywords

Alleles, Body Size, Cognition, Consanguinity, Fertility, Haplotypes, Health Status, Homozygote, Humans, Inbreeding Depression, Risk-Taking